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Article · World Journal of Surgery · April 23, 2020

Prevention of Intra‐abdominal Adhesions by Electrical Stimulation

Ildar Ravisovich Fakhradiyev, Ydyrys A. Almabayev, Timur M. Saliev, Aigul Almabayeva, Baimakhan Tanabayev, Maral Yergazina

Ildar FakhradiyevTimur Saliev
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Abstract

Abstract The study investigated the ability of transdermal electric stimulation to prevent the formation of intra‐abdominal adhesions in the combination with Seprafilm® (anti‐adhesive agent). One hundred and twenty‐eight (128) rabbits were subjected to a surgical procedure to simulate the adhesion processes. After the simulation, the animals were divided into 4 groups (32 animals each), depending on the application of the methods of prevention: (1) control group (no anti‐adhesives or electro‐stimulation) (CG); (2) comparison group (applications of Seprafilm®) (SF); (3) comparison group 2 (transdermal electric stimulation of the abdominal muscles) TES; (4) group (transdermal electric stimulation + Seprafilm®) (TES + SF). We observed that the application of the Seprafilm® alone led to a significant decrease in the adhesive process compared to the control group (CG) (p < 0.01). The adhesion process in the group underwent transdermal electrical stimulation (TES) was significantly lower compared to the Seprafilm® group (SF) (p ≤ 0.05). The results demonstrated a significant decrease in the adhesion processes in the SF + TES group on days 1, 3, 7 and 14 in comparison with the CG group (p = 0.001), SF group (p = 0.001) and TES group (p = 0.01) group of animals. This study showed the efficacy of transdermal electrical muscle stimulation for the prevention of intra‐abdominal adhesions. Moreover, the combination of Seprafilm® anti‐adhesion agent and electrical muscle stimulation resulted in the complete absence of adhesions. Our findings indicate the potential of such strategy for further clinical application.

Intestinal and Peritoneal AdhesionsHernia repair and managementEnhanced Recovery After Surgeryperitoneal adhesionsadhesion preventionneuromuscular electrical stimulation

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